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  • br Herein we reported novel NPs

    2020-08-12


    Herein, we reported novel NPs based on PEO-PBO-loaded LA-SN38 (EBNPs). The EBNPs with small size and narrow distribution, and could effectively control the release rate of SN38. Through in vitro cytotoxi-city and apoptosis assay, we demonstrated EBNPs were more effective in antitumor of human colon cancer cells. Furthermore, cell uptake assay indicated that EBNPs could reduce the U 0126 of macro-phages and promote the uptake of tumor cells. Pharmacokinetic and biodistribution studies confirmed EBNPs had the advantages of pro-longed blood circulation and enhanced tumor targeting ability. In vivo, EBNPs were more effective in inhibiting the growth of tumor than SNPs and CPT-1, and were well tolerated at the tested dose. In summary, EBNPs are shown as a promising candidate for delivery LA-SN38 for treatment of colorectal cancer. Moreover, EBNPs may be useful as a drug carrier for other drugs in other tumor types.
    Declaration of Competing Interest
    There are no conflicts to declare.
    Acknowledgment
    This work was supported by the National Natural Science Foundation of China [grant number 21602206].
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    Contents lists available at ScienceDirect
    Biomedicine & Pharmacotherapy
    journal homepage: www.elsevier.com/locate/biopha
    Anticancer activity of synthetic ( ± )-kusunokinin and its derivative T
    ( ± )-bursehernin on human cancer cell lines
    Thidarath Rattanabureea, Tienthong Thongpanchangb, Krittaphat Wongmac, Aman Tedasena, Yaowapa Sukpondmad, Potchanapond Graidista,e,
    a Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand
    b Department of Chemistry, Faculty of Science and Center of Excellence for Innovation in Chemistry, Mahidol University, Bangkok, 10400, Thailand
    c General Sciences Program, Faculty of Education, Sakon Nakhon Rajabhat University, Sakon Nakhon, 47000, Thailand
    d Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand
    e The Excellent Research Laboratory of Cancer Molecular Biology, Prince of Songkla University, Songkhla, 90110, Thailand
    Keywords: Kusunokinin is a potent lignan compound with a several biological properties including antitrypanosomal and
    Kusunokin anticancer. In this study, ( ± )-kusunokinin and its derivative, ( ± )-bursehernin, were synthesized and in-